The catenins, α,? and y, are proteins which bind to the highly conserved, intracellular cytoplasmic tail of E-cadherin. Together, the catenin/cadherin complexes play an important role mediating cellular adhesion. α-catenin was initially  described as an E-cadherin
associated protein, and since has been shown to associate with other members of the cadherin family, such as N- cadherin and P-cadherin. ?-catenin associates with the cytoplasmic portion of  E-cadherin, which is necessary for the function of E-cadherin as an adhesion molecule. ?-catenin has also been found in complexes with the tumor suppressor  protein  APC. y-catenin, also known as plakoglobin, is a protein that binds with α-catenin and N-cadherin. It has been shown that the
transmembrane phosphatase PTPμ associates with catenin/cadherin complexes and may regulate complex signaling.

P35222 

https://www.uniprot.org/uniprotkb/p35222

92kDa

Mouse

1. Mouse IgG1
   

This Abmart monoclonal antibody is produced by immunizing mice with a synthetic  peptide (KLH-coupled) corresponding to carboxy-terminal  residues of human ?-catenin.

?-Catenin (44C6) Mouse  mAb detects  endogenous  levels of total  ?-catenin protein.

Human, Mouse, Rat

Western blotting                    1:1000
Immunofluorescence           1:200
Immunohistochemistry        1:200

*For Western blots, incubate membrane with diluted antibody in 5% w/v non-fat dry milk,  1× TBS, 0.05% Tween-20  at 4°C with gentle shaking, overnight.

Store at -20°C, stable for one year from the date of shipment.

AB_2920853

#M21001 Goat Anti-Mouse  IgG-HRP